Suggested Use: Take 2 capsules once daily, or as directed by your qualified health care professional.
Warning: Consult a health care professional prior to use if you are pregnant or nursing, taking any medications, or have any medical conditions. Keep out of reach of children.
Store in a cool, dry place.
Ingredients: Trans-Resveratrol from Japanese Knotweed (Polygonum cuspidatum) Root Extract, Organic Potato Starch and Hypromellose (Capsule).
What is Resveratrol?
Resveratrol (3,5,4′-trihydroxystilbene) is a polyphenol most commonly found in red wine and grapes. It is also found in peanuts, certain berries, some pines, and the roots and stalks of Japanese knotweed. Polyphenols act as antioxidants and protect the body against damage that puts you at higher risk for diseases like cancer and heart disease. Research has also shown that resveratrol is a sirtuin activator, and stimulates the activity of other proteins in mitochondrial function as well as metabolism.
What are the benefits?
Scientific interest in resveratrol has continually gained momentum since 1997, when it was first demonstrated to prevent carcinogenesis in mice. In the intervening years, this molecule has received considerable attention for its anti-inflammatory, anti-tumorigenic, and anti-oxidant properties, as well as its ability to increase lifespan in lower organisms and improve general health in mammals. A 2003 study at Harvard University found that resveratrol mimics the effects of caloric restriction in yeast cells, boosting their life spans by as much as 70%. The following year the researchers went on to demonstrate that resveratrol slows aging in two standard laboratory animals, roundworms and fruit flies. There were other studies in fish and larger animals showing extension in lifespan by more than 50%.
Anti-cancer activity: When added to cultured cells, resveratrol inhibited the proliferation of many human cancer cell lines (breast, thyroid, prostate, stomach, pancreatic, colon). Clinical trials have demonstrated that resveratrol supplementation (0.5g to 1g) decreases tumor proliferation significantly in patients with colon cancer, and resveratrol treatment at 2.5 g/day significantly reduces IGF1 and IGFBP3 levels in plasma (associated with tumor formation), which would support the use of resveratrol as a chemo-preventative agent in humans.[5-7]
Cardiovascular benefits: Studies have shown that resveratrol benefits the cardiovascular system by creating a decrease in the oxidation of LDL, lowering platelet aggregation, and promoting relaxation of the small blood vessels (arterioles).[8-11] This decreases the risk of developing atherosclerosis and clotting, which reduces the risk of stroke. Clinical studies have shown improved insulin sensitivity in subjects with impaired glucose tolerance, and improved glycemic control and endothelial function in patients with type 2 diabetes.[12-13] A randomized study in 50 healthy smokers showed that due to the anti-inflammatory, anti-oxidant, and hypotriglyceridemic effects of resveratrol, its supplementation may reduce the cardiovascular risk in healthy smokers. Resveratrol supplementation has been shown to increase flow-mediated vasodilation (decreased FMD is a risk factor for cardiovascular disease in older adults) in obese/overweight individuals with un-medicated borderline hypertension. Studies have also shown increased cerebral blood flow and hemoglobin status in healthy adults.
Resveratrol and Mitochondria: As mentioned above, resveratrol activates proteins involved in mitochondrial function. In rodents, exercise-training effects can be augmented by large doses of resveratrol supplementation. A recent clinical study showed similar effects in humans where supplementation with 500mg of resveratrol with piperine in combination with low-intensity exercise increased skeletal muscle mitochondrial capacity by about 40%.
Why take resveratrol supplements?
Resveratrol concentrations from red wine, grapes, and berries are low and vary widely. A study on bioavailability from wine found that 15 days of 300 mL wine consumption increased plasma resveratrol concentration from 0.72±0.3 to 1.33±0.3 μmol/L for white wine (0.25 g polyphenols/L) and from 0.71±0.2 to 1.72±0.1 μmol/L for red wine (1.8 g polyphenols/ L). In a bioavailability study for supplements, the lowest supplementation dose used (0.5 g) resulted in a 24-h mean plasma concentration of 8.36 μg/L, with a Cmax of 72.6 μg/L at 0.83 h following administration. Therefore supplementation with a similar dose of polyphenols results in higher plasma concentrations compared to consumption via wine or juice.
Doses ranging from 25mg to 5g have shown benefits in different conditions, with no adverse effects. Research has found that an optimal daily dose of resveratrol for healthy adult people would be around 75-250 mg/day, to protect a body from oxidative damage caused by free radicals. A treatment dosage could be up to 500mg/day.
- 1 Jang, M., Cai, L., Udeani, G. O., Slowing, K. V. et al., Cancer chemoprotective activity of resveratrol, a natural product derived from grapes. Science 1997, 275, 218–220.
- 2 Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A. et al., Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444, 337–342.
- 3 Aggarwal BB, Bhardwaj A, Aggarwal RS, et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004 Sep;24(5A):2783-840.
- 4 Nagaoka T, Hein TW, Yoshida A, Kuo L. Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels. Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4232-9.
- 5 Carter LG, D’Orazio JA, Pearson KJ. Resveratrol and cancer: focus on in vivo Endocrine-Related Cancer. 2014;21(3):R209-R225. doi:10.1530/ERC-13-0171.
- 6 Patel KR, Brown VA, Jones DJ, et al. Clinical Pharmacology of Resveratrol and its Metabolites in Colorectal Cancer Patients. Cancer research. 2010;70(19):7392-7399. doi:10.1158/0008-5472.CAN-10-2027.
- 7 Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Research. 2010;70:9003–9011.
- 8 Thirunavukkarasu M, Penumathsa SV, Koneru S, et al. Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med. 2007 Sep 1;43(5):720-9.
- 9 Cullen JP, Morrow D, Jin Y, et al. Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes. Atherosclerosis. 2007 Nov;195(1):e125-33.
- 10 Wu CC, Wu CI, Wang WY, Wu YC. Low concentrations of resveratrol potentiate the antiplatelet effect of prostaglandins. Planta Med. 2007 May;73(5):439-43.
- 11 Opie LH, Lecour S. The red wine hypothesis: from concepts to protective signalling molecules. Eur Heart J. 2007 Jul;28(14):1683-93.
- 12 Jill P. Crandall, Valerie Oram, Georgeta Trandafirescu, Migdalia Reid, Preeti Kishore, Meredith Hawkins, Hillel W. Cohen, Nir Barzilai; Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance. J Gerontol A Biol Sci Med Sci 2012; 67 (12): 1307-1312. doi: 10.1093/gerona/glr235
- 13 Bhatt, Jayesh Kumar, Sabin Thomas, and Moola Joghee Nanjan. “Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus.” Nutrition research7 (2012): 537-541.
- 14 Bo, S., et al. “Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial.” Current medicinal chemistry10 (2013): 1323-1331.
- 15 Smoliga, James M., Joseph A. Baur, and Heather A. Hausenblas. “Resveratrol and health–a comprehensive review of human clinical trials.” Molecular nutrition & food research8 (2011): 1129-1141.
- 16 Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-22.
- 17 Polley, Kristine R., et al. “Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity.” Applied Physiology, Nutrition, and Metabolism1 (2015): 26-32.
|* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.