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Fisetin

Rejuvenation Therapeutics

RTX-DS2100-030

  • Antioxidant support for healthy aging.*
  • Supports cognitive function.*

Suitable for Vegans. Gluten Free. No artificial fillers, No Rice.

30 Vegan Capsules (100mg).

   FREE SHIPPING ON ORDERS OVER $25!

Suggested Use: Take 1 capsule daily, or as directed by your qualified health care professional.

Warning: Consult a health care professional prior to use if you are pregnant or nursing, taking any medications, or have any medical conditions. Keep out of reach of children.

Store in a cool, dry place.

Ingredients: Fisetin (Rhus succedanea), Organic Potato Starch and Hypromellose (Capsule).


What is Fisetin?

Fisetin is a bioactive flavonol molecule found in fruits and vegetables such as strawberry, apple, persimmon, grape, onion, and cucumber at concentrations in the range of 2–160μg/g.[1] Fisetin was found to be one of the potent antioxidant flavonoids among the evaluated flavonoids.[2] It exerts multiple beneficial pharmacological activities such as anti-inflammatory, anti-cancer, hypolipidemic and in rheumatoid arthritis.[3] Fisetin has shown anti-cancer activity in studies on cells and model animals conducted in laboratories.[4]


What are the Benefits of Fisetin?

  • Fisetin has been studied by researchers at the Salk Institute for Biological Studies as a memory enhancer. Laboratory and animal studies have found that it protects and promotes the growth of brain cells and enhances memory in mice.[5]
  • It has been shown to maintain levels of glutathione (the primary antioxidant internal to most cells in the body) in the presence of oxidative stress.
  • Fisetin has been shown to affect multiple pathways involved in the maintenance of neuronal function during aging. It acts as an antioxidant, increases GSH, maintains mitochondrial function in the presence of oxidative stress, has anti-inflammatory activity against microglial cells, and inhibits the activity of 5-lipoxygenase, signifying that fisetin causes reduction in the age-related decline in brain function[2].
  • In addition, it has anti-inflammatory activity and inhibits the activity of lipoxygenases, thereby reducing the production of pro-inflammatory eicosanoids and their by-products. This wide range of actions suggests that fisetin has the ability to reduce the impact of age-related neurological diseases on brain function.[6]
  • It's proven ability toinhibit oxidation of harmful LDL cholesterol also indicates fisetin’s potential in preventing cardiovascular disease.[7]
  • Emerging data fromin vitro andin vivo studies indicate that fisetin possesses antiproliferative properties against several cancers.[1, 8, 9]
  • Fisetin-rich RVS extracts (Rhus verniciflua Stokes) have potential anti-platelet and anti-obesity activities and could be used as a functional food ingredient to improve blood circulation.[10]
  • Fisetinalso inhibits UVB-induced collagen degradation – a key factor in skin aging.[11]

Why Take Fisetin Supplements?

Although present in strawberries, fisetin is a relatively rare nutrient found only in minute quantities in the plant kingdom. Fisetin supplements serve as a convenient option to increase a daily intake of this flavonoid, which has memory enhancing, anti-inflammatory, anti-cancer, anti-platelet and anti-obesity properties.[5, 6, 8-10] It also has potential in preventing cardiovascular diseases.[7]


References

  1. Naghma Khan, Deeba N. Syed, Nihal Ahmad, Hasan Mukhtar. Fisetin: A Dietary Antioxidant for Health Promotion. Antioxid Redox Signal. 2013 Jul 10; 19(2): 151–162.
  2. Maher P (2009) Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutr 4: 297–307.
  3. Leotoing L, Wauquier F, Guicheux J, Miot-Noirault E, Wittrant Y, et al. (2013) The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts. PLoS ONE 8: e68388.
  4. Syed, DN; et al. (Sep 2013). Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin. Anticancer Agents Med Chem. 13 (7): 995–1001.
  5. Pamela Maher. Methods of using flavonoids to enhance memory US 7897637 B2. The Salk Institute For Biological Studies
  6. Maher P(2015) Fisetin acts on multiple pathways to reduce the impact of age and disease on CNS function. Front Biosci (Schol Ed) 7, 58-82
  7. Masternak MM, Bartke A. PPARs in calorie restricted and genetically long-lived mice. PPAR Res. 2007;2007:28436.
  8. Syed DN, Suh Y, Afaq F, Mukhtar H. Dietary agents for chemoprevention of prostate cancer. Cancer Lett. 2008 Jul 8; 265(2):167-76.  
  9. Jankun J, Selman SH, Aniola J, Skrzypczak-Jankun E. Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment. Oncol Rep. 2006 Aug; 16(2):341-6.
  10. Im WK, Park HJ, Lee KS, Lee JH, Kim YD, Kim KH, Park SJ, Hong S, Jeon SH. Fisetin-Rich Extracts of Rhus verniciflua Stokes Improve Blood Flow Rates in Mice Fed Both Normal and High-Fat Diets. J Med Food. 2016 Feb;19(2):120-6
  11. Chiang HM, Chan SY, Chu Y, Wen KC. Fisetin Ameliorated Photodamage by Suppressing the Mitogen-Activated Protein Kinase/Matrix Metalloproteinase Pathway and Nuclear Factor-κB Pathways. J Agric Food Chem. 2015 May 13;63(18):4551-60
  12. Integrative Medicine E-Book. David Rakel Elsevier Health Sciences, 21-Mar-2017 - Medical - 1072 pages
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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