Suggested Use: Take 1 capsule daily, or as directed by your qualified health care professional.
Warning: Consult a health care professional prior to use if you are pregnant or nursing, taking any medications, or have any medical conditions. Keep out of reach of children. Do not take vitamin K supplements if you are taking anticoagulant drugs.
Store in a cool, dry place.
What is Vitamin K2 MK-7?
Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body requires for complete synthesis of certain proteins that are prerequisites for blood coagulation. The body also needs these proteins for controlling binding of calcium in bones and other tissues. Vitamin K includes two natural vitamers: vitamin K1 and vitamin K2. Vitamin K1 is made in plants and algae; green leafy vegetables are a particularly rich source. On the other hand, bacteria generate vitamin K2, which can also be found in meat, dairy, eggs, and fermented foods, such as cheese, yogurt, and natto—a Japanese dish of fermented soybeans
Vitamin K2 or menaquinone, is essential for calcium use, helping build strong bones and inhibiting arterial calcification. It has nine related compounds, generally subdivided into the short-chain menaquinones (with MK-4 as the most important member) and the long-chain menaquinones, of which MK-7, MK-8 and MK-9 are nutritionally the most recognized.
What are the benefits of Vitamin K2 MK-7?
Studies have shown that supplementation with K2MK7 can reduce vascular calcification in patients with CAD, and decreases arterial stiffness post-menopausal women.[2, 3] An adequate intake of vitamin K2 has been shown to lower the risk of vascular damage because it activates matrix GLA protein (MGP), which inhibits the deposits of calcium on the walls.
In another study on K2MK7 for rheumatoid arthritis, in the MK-7 treated group, a marked decrease in RA clinical and biochemical markers was observed.
Why take Vitamin K2 MK-7 supplements?
Vitamin K, particularly as vitamin K2, is present in very little amounts even in a healthy Western diet. Vitamin K deficiency results in inadequate activation of MGP, which greatly impairs the process of calcium removal and increases the risk of calcification of the blood vessels. An increased intake of vitamin K2 could therefore lower calcium-associated health risks. Vitamin K2 is most active as the MK-7 form, which is present in natto. Research has shown that increased consumption of MK-7 leads to more activated osteocalcin, which is linked to increased bone-matrix formation and bone mineral density and, therefore, a lower risk of hip fracture.[5, 6] Those results were confirmed in a 3-year study with 944 women aged 20 to 79 years, which showed that intake of MK-7-rich natto was associated with the preservation of bone mineral density. One recent, double-blind, randomized clinical trial investigated the effects of supplemental MK-7, MenaQ7 (NattoPharma ASA, Hovik, Norway), within a 3-year period for a group of 244 postmenopausal women. The researchers found that a daily dose of 180 mcg was enough to improve bone mineral density, bone strength, and cardiovascular health.
- Schurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. 2007 Apr 15; 109(8):3279-83.
- Vossen, Liv M., et al. “Menaquinone-7 supplementation to reduce vascular calcification in patients with coronary artery disease: rationale and study protocol (VitaK-CAC Trial).” Nutrients11 (2015): 8905-8915.
- Knapen, M. H., et al. “Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial.” Thromb Haemost5 (2015): 1135-44.
- Abdel-Rahman, Mahran S., Eman AM Alkady, and Sameh Ahmed. “Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study.” European journal of pharmacology 761 (2015): 273-278.
- Kaneki M, Hodges SJ, Hosoi T, et al. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. 2001;17(4):315–321.
- Schurgers LJ, Spronk HM, Soute BA, Schiffers PM, DeMey JG, Vermeer C. Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. 2007;109(7):2823–2831.
- Ikeda Y, Iki M, Morita A, et al. Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study.J Nutr. 2006;136(5):1323–1328.
- Knapen MH, Schurgers LJ, Vermeer C. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int. 2007;18(7):963–972.
|* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.